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KMID : 0614620140640040206
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Korean Journal of Gastroenterology
2014 Volume.64 No. 4 p.206 ~ p.212
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Clinical Correlation between Serum Cytokeratin-18 and Metabolic Parameters in Patients with Sonographic Non-alcoholic Fatty Liver Disease
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Kwak Dong-Shin
Jun Dae-Won
Cho Young-Kyun
Lee Seung-Min
Lee Sae-Hwan
Jung In-Sub
Lee Sung-Won
Lee Jung-Hoon
Lee Eun-Young
Rho Min
Lee Kang-Lok
Ko Jun-Kwon
Park Soon-Eung
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Abstract
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Background/Aims: The serum cytokeratin-18 (CK-18) has been suggested to be a surrogate marker of non-alcoholic fatty liver disease (NAFLD). The aim of this study was to investigate the correlation between CK-18 and metabolic parameter in NAFLD patients. Correlation between CK-18 and macronutrient composition was also assessed.
Methods: A total of 212 subjects were recruited. Blood chemistry including fasting glucose, cholesterol level, AST, ALT, and CK-18 were compared. Data on calorie intake and carbohydrate consumption were acquired by five-day-diet diary using 24 hour recall method.
Results: Plasma CK-18 were markedly increased in patient with NAFLD compared with control group (420.4±282.3 vs. 313.6±179,p＜0.001). Plasma CK-18 were positively correlated with systolic blood pressure (r=0.130), ALT (r=0.503) and negatively correlated with HDL cholesterol (r=?0.246). NAFLD patients with metabolic syndrome had higher CK-18 level than those without metabolic syndrome (484.0 vs. 372.1 U/L, p=0.021). When NAFLD patients were subdivided into two groups with CK-18 cut-off value of 400 U/L, patients with CK-18 level over 400 U/L showed higher body mass index (28.0±4.5 vs. 25.5±4.3), subcutaneous abdominal fat (283.5±172.2 vs. 195.7±147.8), AST (52.7±26.3 vs. 40.7±23.5) and ALT (102.0±52.6 vs. 61.2±32.2). Calorie intake (r=0.301) and carbohydrate intake (r=0.305) also showed positive correlation with CK-18.
Conclusions: Plasma CK-18 showed positive correlation with metabolic parameters as well as calorie and carbohydrate intake when its cut-off value of greater than 400 U/L was used.
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KEYWORD
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Non-alcoholic fatty liver disease, Keratin-18, Metabolic syndrome, Carbohydrates
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